Ethan Hunt (Tom Cruise), while vacationing, is alerted by the IMF that someone has used his identity to assist Russian bio-chemical expert Dr. Vladimir Nekhorvich (Rade Serbedzija) of Biocyte Pharmaceuticals to enter into the United States, but purposely crashed the commercial airline en route. Nekhorvich, an old friend of Hunt, had forewarned the IMF of his arrival, planning to deliver a new virus called Chimera and its cure, Bellerophon, both of which he was forced to develop by Biocyte, into the IMF's hands. With the crash of the plane, IMF is worried that the virus is out in the open, believing that former IMF agent Sean Ambrose (Dougray Scott) is behind the incident. IMF assigns Hunt to recover it. Hunt is told that he can use two members of his team to help him, but the third person to help him must be Nyah Nordoff-Hall (Thandie Newton), a professional thief presently operating in Seville, Spain as she will be able to get close to Ambrose.
After recruiting Nyah, Hunt meets his team, computer expert Luther Stickell (Ving Rhames) and pilot Billy Baird (John Polson) in Sydney, Australia, where Biocyte laboratories are located along with Ambrose's headquarters. As Hunt and the others stake out Biocyte, Nyah gets close to Ambrose and begins to find any information related to the Chimera virus. At a horse racing event, Ambrose quietly meets with Biocyte's CEO, John C. McCloy (Brendan Gleeson), and shows him a video of the Chimera virus affecting one of Nekhorvich's colleagues taken from Biocyte, using the footage to force McCloy to cooperate with them. Nyah is able to steal the video footage long enough to transfer it to Hunt and his team, who learn that the Chimera virus has a 20 hours dormant period before it causes death through mass destruction of the victim's red blood cells; Bellerophon can only save the victim if used within the 20 hours.
After recruiting Nyah, Hunt meets his team, computer expert Luther Stickell (Ving Rhames) and pilot Billy Baird (John Polson) in Sydney, Australia, where Biocyte laboratories are located along with Ambrose's headquarters. As Hunt and the others stake out Biocyte, Nyah gets close to Ambrose and begins to find any information related to the Chimera virus. At a horse racing event, Ambrose quietly meets with Biocyte's CEO, John C. McCloy (Brendan Gleeson), and shows him a video of the Chimera virus affecting one of Nekhorvich's colleagues taken from Biocyte, using the footage to force McCloy to cooperate with them. Nyah is able to steal the video footage long enough to transfer it to Hunt and his team, who learn that the Chimera virus has a 20 hours dormant period before it causes death through mass destruction of the victim's red blood cells; Bellerophon can only save the victim if used within the 20 hours.
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